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Department Seminar

Supported by The Allergan Foundation

Upcoming Seminar

The Chemical Logic of Natural Product Biosynthesis
Dr. Yi Tang, UCLA

December 1, 2021
4:00pm in HSCI-102

Yi Tang

Enzymes from natural product biosynthetic pathways catalyze the biosynthesis of complex molecules. While the core enzymes prepare the carbon backbones of natural products, enzymes involved in precursor biosynthesis and tailoring steps are particularly attractive as potential biocatalysts. These enzymes include group transferases, oxidative enzymes and pericyclases, etc. Many of the observed regio-, stereo-, and peri-selective reactions are synthetically challenging or without synthetic parallels. In this presentation, I will present enzymes discovery efforts in my laboratory in recent years, with an emphasis on enzymes that catalyze pericyclic reactions and use pyridoxal phosphate (PLP) as cofactor. I will present the sources of discovery through genome mining, characterization and application of the these enzymes.

Royal Society of Chemistry cover - Natural Product Biosynthesis
Fig. Cover of Royal Society of Chemistry - Natural Product Biosynthesis, Chemical Logic and Enzymatic Marchinery. Christopher T. Walsh and Yi Tang.

Seminars are held on Wednesdays at 4:00pm. All are invited to attend.

For seminars held via Zoom, faculty, staff, alumni, and students of the department will automatically receive a weekly invitation via email. All others may email the Seminar Coordinator for invitation.

Schedule for Fall 2021

Date Title Speaker and Affiliation
September 1 Anatomy of chemical reactions: Catalytic oxidation of carbon monoxide Dr. Jerry LaRue, Chapman University
September 8 Enzymatic Oxidative Coupling Reactions to Make Protein Therapeutics Dr. Matthew Francis, UC Berkeley
September 15 Examining the morphology and chemical reactivity of 2D and 3D carbon structures Dr. Michael Groves, CSU Fullerton
September 29 Connecting DNA Shape with CRISPR Target Discrimination: Mechanistic Insights Informing Applications Dr. Peter Qin, USC
October 6 Reaction Networks and the Metric Structure of Chemical Space(s) Dr. Dmitrij Rappoport, UC Irvine
October 13 Strange things happen at the nanoscale: Spectroscopy, entropy and quantum effects at solid/liquid interfaces Dr. Tod Pascal, UC San Diego
October 20 Small molecule electrocatalysis and interfacial charge speciation Dr. Hadi Tavassol, CSU Long Beach
October 27 Actin in self-defense: How the cytoskeleton protects neurons during cerebral ischemia and energy stress Dr. Shelley Halpain, UC San Diego
November 10 A Tale of DNA Modifications: Chemistry, Biology, and Applications Dr. Linlin Zhao, UC Riverside
November 17 The Role of Electric Fields and Aqueous Solvation for Catalyst Design / From photons to fuels by computation: Modeling electrocatalytic reduction of CO2 on copper electrodes Drs. Teresa Head-Gordon and Martin Head-Gordon, UC Berkeley
December 1 The Chemical Logic of Natural Product Biosynthesis Dr. Yi Tang, UCLA
December 8 TBD David Elsenberg, UCLA

Previous Seminars

The following are Seminars from previous semesters.

Spring 2021

Date Title Speaker and Affiliation
April 28 Development of multitarget inhibitors for the
treatment of pain: design, synthesis, biological
evaluation and molecular modeling studies
Dr. Stevan Pecic, CSU
Fullerton
April 21 Earth-Abundant Metal Catalysis: Mechanisms of CC
and C-Heteroatom Bond Forming Reactions
Dr. Xiaotai Wang, University of
Colorado,
Denver
April 14 Proteins and Drugs Controlling Cancer Cell
Division
Dr. Seth Rubin, US Santa Cruz
April 7 The Bioinorganic Chemistry of the Simple Nitrogen
Oxides (NOx): Not So Simple
Dr. George Richter-
Addo, University of
Oklahoma
March 24 The Fifth Element in Disguise Dr. Shiyuan Liu, Boston College
March 17 Single-Molecule Imaging of the Electrochemical
Interface
Dr. Bo Zhang, University of Washington
March 10 Recombinant protein-polymers in medicine and
biology
Dr. Andrew MacKay, USC
February 17 Uncovering the proteomes and transcriptomes of
cellular protrusions using Laser capture
Microdissection
Dr. Karine Gousset, CSU Fresno
February 10 Fast and Accurate Quantum Chemistry Simulation
for molecular design and discovery
Dr. Fang Liu, Emory University
February 3 Cheminformatics: Using SWIF's to Identify Binding Modes in Non-Covalent Complexes Dr. Eric Sorin, CSU Long Beach
February 3 Stepping into Light: Developing a General Photo-
Initiated Hydroacylation of Alkenes
Dr. Paul Buonora, CSU Long Beach

Spring 2020

Note: most of the Spring 2020 seminars were cancelled due to COVID-19.

Date Title Speaker and Affiliation
March 11, 2020 From Photooxidation to Photobasicity: Adventures Exploring Photochemistry with Undergrads Dr. Andrew Petit, CSU Fullerton
March 4, 2020 Oxylipins and HDL, an explanation for pro- and anti-inflammatory activities Dr. Gregory Shearer, Penn State
February 26, 2020 Epitope-Targeting Cyclic Peptides as Chemical Biology Tools Dr. Min Xue, UC Riverside
February 19, 2020 Twists and turns along the path of reactivity-driven methodology development Dr. Hosea Nelson, UCLA