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C.
LECTURE TIMES AND VENUE:
Lectures will be held in LA-5 Room 357 Tuesdays and Thursdays, 2.00 -3.15
a.m. You are responsible for all announcements, assignments, handouts,
etc. even if you are late or absent from class.
There is no required textbook for this class. However, information
relevant to many of the lectures can be found in the following text books which
are recommended as reading and for general reference.
Recommended Texts:
Principles of
Ecotoxicology, Third Edition
(Paperback). ISBN:084933635X, ISBN 13:9780849336355.
Author(s): Walker, C.H., S. P. Hopkin R.
M. Sibly. Published by: Taylor & Francis.
Fundamentals of Aquatic Toxicology. Effects,
Environmental Fate and Risk Assessment. 2nd Ed. Ed G.
Rand. Taylor and Francis. Philadelphia,
London. ISBN 1-56032-091-5
Quantitative Chemical Analysis. 2011. 8th Edition. Harris, D.C. W.H.
Freeman and Company, New York. ISBN-10 1-4292-1815-0. ISBN-13 978-1-4292-1815-3.
QD101.2.H37
Exploring Chemical Analysis. 2008. 4th Edition. Harris, D.C. W.H. Freeman and Company, New York.
ISBN: 978-1-4292-1004-1. QD75.2.H368
Aquatic Toxicology: Molecular,
Biochemical, and Cellular Perspectives:
Donald C. Malins and
Gary K. Ostrander. 1993,
Lewis Publishers, Inc.; 520 pp., ISBN: 0-87371-545-4
Metal Speciation and Bioavailability in Aquatic
Systems. International Union of Pure and Applied
Chemistry series (IUPAC). Chapter 10 Metal
Detoxification in Aquatic Organisms. Pp 479-609.
J. Wiley Publishers. (Eds. A. Tessier and D.R.
Turner).
LECTURE OUTLINE: A general lecture outline is given below
describing some of the topics that will be discussed in lecture.
Depending upon the depth and breadth of the subject matter, various topics
may cover more than an individual lecture period. In addition, to
demonstrate the analytical complexities of undertaking direct chemical analyses
in an ecotoxicological study, the class will undertake a field trip to collect
sediment and infaunal invertebrate samples for direct chemical analyses from
Colorado Lagoon, a locally impacted lagoon which will be undergoing remediation
and restoration in the near future. Consequently, no
attempt has been made to allocate dates to the various lectures given in the
table below.
| Lecture |
Topic |
| 1 |
Outline of Course Syllabus & Introduction to Aquatic
Toxicology. |
| 2 |
Major Classes of Pollutants (Inorganics, Organics, Radiation
etc) |
| 3 |
Routes by Which Pollutants Enter the Aquatic Ecosystems. |
| 4 |
Direct Chemical methods
for the identification, quantification and speciation of inorganic
pollutants |
| 5 |
Direct Chemical methods
for the identification, quantification and speciation of organic
pollutants |
| 6 |
In Situ biomonitoring systems for water quality assessment |
| 7 |
Determination of Toxicity:
Toxicity
Testing. Trials and Tribulations |
| 8 |
Toxicity Assessment: End
points in Toxicity (Acute versus Chronic; Lethal vs physiological) |
| 9 |
Behavioral responses to toxicants |
| 10 |
Physiological responses to toxicants |
| 11 |
Biochemical responses to toxicants |
| 12 |
Cellular and Molecular responses to toxicants |
| 13 |
Biomarkers of Xenobiotic Stress (organismal, cell/tissue,
subcellular) |
| 14 |
Biomarkers of Xenobiotic Stress (Alarm parameters, Toxicity
stress/strain parameters/ Finger print parameters) |
| 15 |
Molecular Mechanisms of interaction of Inorganics
(Metallothioneins) |
| 16 |
Molecular Mechanisms of interaction of Organics
(Cytochrome
P-450) |
| 17 |
Recombinant reporter assays for Toxicological Assessment |
| 18 |
Case Studies in Toxicology (Cytochrome P-450 induction
and Endocrine Disruption by TBT). |
| 19 |
|
| 20-24 |
STUDENT PRESENTATIONS
I - IV (see below) |
| 25 |
FINAL
EXAM: Thursday, May 19th,
LA5-357
12.30 - 2.30 p.m. |
|
|
|
|
Presentation Schedule |
|
Barillas,Pablo Jose |
iodine 131/125 |
March 3rd -
1 |
|
Fellerman,Raymond George |
Lead, |
March 3rd -
2 |
|
Ma,Te |
Se |
March 3rd -
3 |
|
Morfin,
Hector |
Cu |
March 3rd -
4 |
|
Chow,Karen
Wing Yi |
Methoxychlor |
March 3rd -
5 |
|
Yip,Michael
K |
nanoparticles |
March 3rd -
6 |
|
Desgens
Martin,Violaine |
TBT and Cr |
March 3rd -
7 |
|
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|
|
|
Lyons,Katherine DH |
PCB, benzo(a)pyrene |
March 5th -
1 |
|
Watts,Ashley
Christine |
DDT |
March 5th -
2 |
|
Chiu,Gabriel
C |
E2 |
March 5th -
3 |
|
Gagnon,Courtney Alexandria |
Cd |
March 5th -
4 |
|
Overlin,Lyndsey SueAnne |
Ni |
March 5th -
5 |
|
Young,Jessica Marie |
Zn |
March 5th -
6 |
|
Wickremasinghe Harshini |
Hg |
March 5th -
7 |
|
Stanton,Laura Allison |
As |
March 5th -
8 |
|
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|
|
Friends of the Colorado Lagoon - Taylor Parker
Metal
analyses by ICP-MS - Andrew Hamilton
Organics Analysis by GCMS - Mary Blasius
Certified Reference Material 1747
Enzyme Inhibition
Lecture 1
Lecture 2
Lecture 3
Lecture 4 -
Cytochrome P- 450
Certified
reference Material 1944 Sediment
Additional
Information on Toxicology report
Basics of GC-MS - Mary Blasius Lecture
Phase2 enzymes
TBT-induced Imposex
Biomarkers
Endocrine Disruption
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