PSYCHOLOGY MASTER'S THESIS ABSTRACT

Karrie N. Berg
MA-Research
December 1999

The Ability of 7-OH-DPAT to Decrease Dopamine Release During Periods of Anticipation,
and Thus Prevent the Subsequent Cravings Associated with Drug Addiction

    This study looked at the ability of 7-OH-DPAT to decrease the cravings associated with drug addiction.  Learning theories explain that the environment takes on the ability to stimulate dopamine release, leading to drug cravings.  It was hypothesized that a low dose (.04 mg/kg) of 7-OH-DPAT would reduce an amphetamine produced conditioned place preference (CPP).  It was also hypothesized that a high dose of 7-OH-DPAT (4 mg/kg) would potentiate a CPP.

    Fifty-four rats were randomly assigned to six groups.  The animals were conditioned with amphetamine in a CPP compartment.  They were then given the assigned dose of 7-OH-DPAT and tested for a CPP and locomotion.  A 2 x 3 x 2 mixed design was used to analyze the data.  CPP data showed a main effect of conditioning and a main effect of 7-OH-DPAT dosage.  Locomotion data showed a main effect of 7-OH-DPAT dosage.  Simple comparisons show that tolerance mechanisms may be present.

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