Dr. Alexander Lynn Beckman's Publications

Original Papers and Chapters:

Reynolds, R.W. and A.L. Beckman.  A transient-free operandum for use with electrophysiological recording.  J. Exp. Anal. Behav. 10:564, 1967.

Beckman, A.L. and H.J. Carlisle.  Effect of intrahypothalamic infusion of acetylcholine on behavioral and physiological thermoregulation in the rat.  Nature 221:561-562, 1969.

Beckman, A.L.  Effect of intrahypothalamic norepinephrine on thermoregulatory responses in the rat.  Am. J. Physiol. 218:1596-1604, 1970.

Beckman, A.L. and J.S. Eisenman.  Microelectrophoresis of biogenic amines on hypothalamic thermosensitive cells.  Science 170:334-336, 1970.

Beckman, A.L. and E. Satinoff.  Arousal from hibernation by intrahypothalamic injections of biogenic amines in ground squirrels.  Am. J. Physiol. 222:875-879, 1972.

Beckman, A.L. and E. Rozkowska-Ruttiman.  Hypothalamic and septal neuronal responses to iontophoretic application of salicylate in rats.  Neuropharmacology 13:393-398, 1974.

Beckman, A.L., E. Satinoff, and T.L. Stanton.  Characterization of midbrain component of the trigger for arousal from hibernation.  Am. J. Physiol. 230:368-375, 1976.

Beckman, A.L., T.L. Stanton, and E. Satinoff.  Inhibition of the CNS trigger process for arousal from hibernation.  Am. J. Physiol. 230:1018-1025, 1976.

Beckman, A.L. and T.L. Stanton.  Changes in CNS responsiveness during hibernation.  Am. J. Physiol. 231:810-816, 1976.

Beckman, A.L., T.L. Stanton, and E. Satinoff.  Thermal responses during hibernation following brainstem microinjections of acetylcholine in Citellus lateralis.  Israel J. Med. Sci. 12: 1118-1121, 1976.

Stanton, T.L. and A.L. Beckman.  Thermal changes produced by intrahypothalamic injection of acetylcholine during hibernation and euthermia in Citellus lateralis.  Comp. Biochem. Physiol. 58A:143-150, 1977.

Winokur, A. and A.L. Beckman.  Principles of neurophysiology.  In: Biological Basis of Psychiatric Disorders.  Edited by A. Frazer and A. Winokur.  New York: Spectrum, 1977, pp. 23-29.

Winokur, A. and A.L. Beckman.  Effects of thyrotropin releasing hormone, norepinephrine and acetylcholine on the activity of neurons in the hypothalamus, septum, and cerebral cortex of the rat.  Brain Res. 150:205-209, 1978.

Beckman, A.L.  Hypothalamic and midbrain function during hibernation.  In: Current Studies of Hypothalamic Function.  Edited by K. Lederis and W.L. Veale.  Basel: Karger, 1980, Vol. 2, pp. 29-43.

Beckman, A.L., E. Rozkowska-Ruttiman, and A. Winokur.  Responses of hypothalamic thermosensitive neurons to iontophoretically applied biogenic amines in rats and ground squirrels.  In: Thermoregulatory Mechanisms and Their Therapeutic Implications.  4th Int. Symp. on the Pharmacology of Thermoregulation, Oxford 1979.  Edited by B. Cox, P. Lomax, A.S. Milton and E. Schonbaum.  Basel: Karger, 1980, pp. 6-8.

Baldino, F., Jr., A.L. Beckman, and M.W. Adler.  Effects of iontophoretically applied morphine on rat hypothalamic thermosensitive neurons.  In: Thermoregulatory Mechanisms and Their Therapeutic Implications.  4th Int. Symp. on the Pharmacology of Thermoregulation, Oxford 1979.  Edited by B. Cox, P. Lomax, A.S. Milton, and E. Schonbaum.  Basel: Karger, 1980, pp. 157-158.

Stanton, T.L., A.L. Beckman, and A. Winokur.  Effect of intrahippocampal TRH on body temperature in hibernating and awake ground squirrels.  In: Thermoregulatory Mechanisms and Their Therapeutic Implications.  4th. Int. Symp. on the Pharmacology of Thermoregulation, Oxford 1979.  Edited by B. Cox, P. Lomax, A.S. Milton, and E. Schonbaum.  Basel: Karger, 1980, pp. 195-197.

Stanton, T.L., A. Winokur, and A.L. Beckman.  Reversal of natural CNS depression by TRH action in the hippocampus.  Brain Res. 181:470-475, 1980.

Baldino, F., Jr., A.L. Beckman, and M.W. Adler.  Actions of iontophoretically applied morphine on hypothalamic thermosensitive units.  Brain Res. 196:199-208, 1980.

Beckman, A.L., C. Llados-Eckman, T.L. Stanton, and M.W. Adler.  Physical dependence on morphine fails to develop in the hibernating state.  Science 212:1527-1529, 1981.

Salzman, S.K. and A.L. Beckman.  The effects of thyrotropin releasing hormone on hypothalamic thermosensitive neurons of the rat.  Brain Res. Bull. 7:325-332, 1981.

Stanton, T.L., A.L. Beckman, and A. Winokur.  Thyrotropin-releasing hormone effects in the central nervous system: Dependence on arousal state.  Science 214:678-681, 1981.

Beckman, A.L. and T.L. Stanton.  Properties of the CNS during the state of hibernation.  In: The Neural Basis of Behavior.  Edited by A.L. Beckman.  New York: Spectrum, 1982, pp. 19-45.

Beckman, A.L., C. Llados-Eckman, T.L. Stanton, and M.W. Adler.  Seasonal variation of morphine physical dependence.  Life Sci. 30:147-153, 1982.

Baldino, F., Jr. and A.L. Beckman.  Effects of iontophoretically applied (+)- and (-)-naloxone on rat hypothalamic and septal neurons.  Brain Res. 232:247-252, 1982.

Stanton, T.L., A. Winokur, and A.L. Beckman.  Seasonal variation in TRH content of different brain regions and the pineal in the mammalian hibernator, Citellus lateralis.  Regul. Peptides 3:135-144, 1982.

Beckman, A.L., C. Llados-Eckman, T.L. Stanton, and M.W. Adler.  Differential effect of environmental temperature on morphine physical dependence and abstinence.  Life Sci. 30:1013-1020, 1982.

Beckman, A.L., C. Llados-Eckman, S.K. Salzman, and T.L. Stanton.  Modulation of opioid physical dependence during the hibernation cycle.  NIDA Res. Monogr. 54:209-238, 1984.

Beckman, A.L. and C. Llados-Eckman.  Antagonism of brain opioid peptide action reduces hibernation bout duration.  Brain Res. 328:201-205, 1985.

Salzman, S.K., C. Llados-Eckman, and A.L. Beckman.  In vivo analysis of dopamine and its metabolites in the caudate nucleus during euthermia and hibernation.  Brain Res. 343:95-103, 1985.

Salzman, S.K., M.S. Sellers, A.L. Beckman, R. Naidu, and G.D. MacEwen.  Determination of intraoperative plasma catecholamine concentrations using liquid chromatography with electrochemical detection.  J. Chromatography 343:285-301, 1985.

Stanton, T.L., N. Sartin, and A.L. Beckman.  Changes in body temperature and metabolic rate following microinjection of met-enkephalinamide in the preoptic/anterior hypothalamus of rats.  Regul. Peptides 12:333-343, 1985.

Salzman, S.K., A.L. Beckman, H.G. Marks, R. Naidu, W.P. Bunnell, and G.D. MacEwen.  Effects of halothane on intra-operative scalp-recorded somatosensory evoked potentials to posterior tibial nerve stimulation in man.  Electroenceph. Clin. Neurophysiol. 65:36-45, 1986.

Beckman, A.L. and C. Llados-Eckman.  Morphine distribution following infusion into lateral ventricle during hibernation and euthermia.  Brain Res. Bull. 16:289-297, 1986.

Beckman, A.L.  Functional aspects of brain opioid peptide systems in hibernation.  In: Living in the Cold: Physiological and Biochemical Adaptations.  Edited by H.C. Heller, X.J. Musacchia, and L.C.H. Wang.  New York: Elsevier, 1986, pp. 225-234.

Beckman, A.L., R.R. Dean, and J.K. Wamsley.  Hippocampal and cortical opioid receptor binding: Changes related to the hibernation state.  Brain Res. 386:223-231, 1986.

Salzman, S.K., C. Llados-Eckman, and A.L. Beckman.  Release and metabolism of dopamine and serotonin in the caudate nucleus during euthermia and hibernation.  Ann. N.Y. Acad. Sci. 473:267-283, 1986.

Salzman, S.K., E. Hirofuji, C. Llados-Eckman, G.D. MacEwen, and A.L. Beckman.  Monoaminergic responses to spinal trauma: Evidence for the participation of serotonin in the post- traumatic progression.  J. Neurosurg. 66:431-439, 1987.

Salzman, S.K., P.B. Knight, E. Hirofuji, C. Llados-Eckman, A.L. Beckman, and A. Winokur.  Spinal cord immunoreactive TRH is altered after local traumatic injury.  Peptides 8:247-250, 1987.

Salzman, S.K., E. Hirofuji, P. Knight, C. Llados-Eckman, A.L. Beckman, and A. Winokur.  Treatment of experimental spinal trauma with thyrotropin releasing hormone: central serotonergic and vascular mechanisms of action.  J. CNS Trauma 4:181-196, 1987.

Sarwark, J.F., K.W. Dabney, S.K. Salzman, T. Wakabayashi, H.K. Kitadai, J.T. Beauchamp, A.L. Beckman, and W.P. Bunnell.  Experimental scoliosis in the rat.  I. Methodology, anatomic features and neurologic characterization.  Spine 13:466-471, 1988.

Dabney, K.W., S.K. Salzman, T. Wakabayashi, J.F. Sarwark, G.-X. Gao, A.L. Beckman, and W.P. Bunnell.  Experimental scoliosis in the rat.  II. Biomechanical analysis of the forces during Harrington distraction.  Spine 13:472-477, 1988.

Salzman, S.K., K.W. Dabney, A.A. Mendez, J.T. Beauchamp, J.C. Daley, G.M. Freeman, A. Fonseca, E.B. Ingersoll, A.L. Beckman, and W.P. Bunnell.  The somatosensory-evoked potential predicts neurologic deficits and serotonergic pathochemistry after spinal distraction injury in experimental scoliosis.  J. Neurotrauma 5: 173-186, 1988.

Salzman, S.K., A.A. Mendez, K.W. Dabney, J.C. Daley, G.M. Freeman, S. El-Tantawi, A.L. Beckman, and W.P. Bunnell.  Serotonergic response to spinal distraction trauma in experimental scoliosis.  J. Neurotrauma 8:45-54, 1991.

Beckman, A.L., C. Llados-Eckman, and T.L. Stanton.  Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin.  Brain Res. 588:159-163, 1992.

Beckman, A.L., T.A. Beaver, and F.A. Lewis.  Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia.  Life Sci. 52:1079-1086, 1993.

Schrater, P.S., A.C. Russo, T.L. Stanton, J.R. Newman, L.M. Rodriguez, and A.L. Beckman.  Changes in striatal dopamine metabolism during the development of morphine physical dependence in rats: observations using in vivo microdialysis.  Life Sci. 52:1535-1545, 1993.

Beaver, T.A., F.C. Lewis, J.R. Newman, and A.L. Beckman.  Quantitative and qualitative aspects of the hibernation-related reduction of morphine physical dependence in the ground squirrel (Citellus lateralis).  J. Pharmacol. Exp. Ther. 274:1142-1153, 1995.

 Mosser, H.C., R.R. Boucher, T.M. MacCreadie, J.R. Newman, and A.L. Beckman.  Morphine antinociception in the non-hibernating and hibernating states of the ground squirrel (Citellus lateralis).  Life Sci. 57:1441-1449, 1995.

Sallmen, T., A.L. Beckman, T.L. Stanton, K.S. Eriksson, J. Tarhanen, L. Tuomisto, and P. Panula.  Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation.  J. Neurosci. 19: 1824-1835, 1999.

Books:

Beckman, A.L.  (Editor), The Neural Basis of Behavior. New York: Spectrum, 1982.

Abstracts:

Beckman, A.L. and J.S. Eisenman.  Responsiveness of temperature sensitive hypothalamic neurons to microelectrophoretically applied amines in rats and cats.  Fed. Proc. 29:523, 1970.

Beckman, A.L. and E. Satinoff.  Arousal from hibernation and changes in body temperature following intrahypothalamic chemical stimulation in Citellus lateralis.  Cryobiology 8:311, 1971.

Satinoff, Ed., A.L. Beckman, and L. Kormi.  Effects of intracerebral injection of biogenic amines on hibernation and thermoregulation in the ground squirrel.  Proc. Internat. U. Physiol. Sci. 9:464, 1971.

Beckman, A.L. and L. Amini-Kormi.  Responses of rat hypothalamic thermosensitive cells to iontophoretically applied sodium salicylate.  Intern. J. Biometeor. 16 (Suppl. 5):37, 1972.

Beckman, A.L. and L. Amini-Kormi.  Responsiveness of rat hypothalamic thermosensitive and non-thermosensitive neurons to iontophoretically applied sodium salicylate.  Fifth International Congress on Pharmacology, Abstracts of Volunteer Papers, 1972, p. 17.

Beckman, A.L., T.L. Stanton, and E. Satinoff.  Thermal responses and arousal from hibernation following midbrain chemical stimulation in Citellus lateralis.  Fed. Proc. 33:423, 1974.

Stanton, T.L. and A.L. Beckman.  A comparison of thermal responses during euthermia and hibernation following acetylcholine stimulation in the rostral brainstem.  Fed. Proc. 35:640, 1976.

Beckman, A.L. and A. Winokur.  Effect of thyrotropin releasing hormone on rat hypothalamic and septal neurons: comparison with norepinephrine and acetylcholine.  Soc. Neurosci. Abstr. 3:403, 1977.

Stanton, T.L. and Beckman, A.L.  Evidence for changes in CNS responsiveness following hypothalamic stimulation during hibernation in ground squirrels (Citellus lateralis).  Soc. Neurosci. Abstr. 3:206, 1977.

Beckman, A.L.  Preliminary observations of hypothalamic single unit activity in arousing and unanesthetized euthermic ground squirrels.  J. Thermal Biol. 3:93, 1978.

Stanton, T.L., A. Winokur, and A.L. Beckman.  Thyrotropin releasing hormone: arousing action in the hibernating ground squirrel.  Soc. Neurosci. Abstr. 4:415, 1978.

Baldino, F., Jr., A.L. Beckman, and M.W. Adler.  Actions of iontophoretically applied morphine on rat hypothalamic temperature-sensitive neurons.  Soc. Neurosci. Abstr. 5:548, 1979.

Beckman, A.L., T.L. Stanton, C. Eckman, M.W. Alder, and S. Glassman.  Comparison of morphine abstinence syndrome in awake and hibernating ground squirrels.  Soc. Neurosci. Abstr. 5:549, 1979.

Beckman, A.L. and C. Llados-Eckman.  Failure of morphine to produce physical dependence following central administration during hibernation.  Soc. Neurosci. Abstr. 6:37, 1980.

Salzman, S.K. and A.L. Beckman.  Effects of TRH, NE, and ACh on rat hypothalamic thermosensitive neurons.  Soc. Neurosci. Abstr. 6:216, 1980.

Stanton, T.L., A. Winokur, and A.L. Beckman.  Seasonal variation in TRH content of different brain regions in the hibernator, Citellus lateralis.  Soc. Neurosci. Abstr. 7:32, 1981.

Baldino, F., Jr. and A.L. Beckman.  Stereospecific effects of naloxone on rat hypothalamic and septal neurons.  Soc. Neurosci. Abstr. 7:52, 1981.

Salzman, S.K., M.S. Sellers, and A.L. Beckman.  The effects of TRH on the in vivo release of NE from the medial preoptic/anterior hypothalamus of the rat.  Soc. Neurosci. Abstr. 7:151, 1981.

Stanton, T.L., A. Winokur, and A.L. Beckman.  Concentrations of TRH in brain regions of the ground squirrel during different seasons and in the state of hibernation.  Neuroendocrinol. Lett. 3:106, 1981.

Beckman, A.L. and S.K. Salzman.  Effects of iontophoretically applied met- and leu-enkephalin on hypothalamic thermosensitive neurons in the rat.  The Physiologist 25:305, 1982.

Stanton, T.L. and A.L. Beckman.  Behavioral and physiological thermoregulatory responses following central administration of thyrotropin-releasing hormone in ground squirrels.  The Physiologist 25:305, 1982.

Llados-Eckman, C. and A.L. Beckman.  Reduction of hibernation bout duration by ICV infusion of naloxone in Citellus lateralis.  Soc. Neurosci. Abstr. 9:796, 1983.

Chin, R., A.L. Beckman, and G.D. MacEwen.  Scoliosis and absence of vascular changes in the spinal cord after dorsal rhizotomy.  J. Bone Joint Surg. Orthopaedic Transactions.  Proceedings 18th Ann. Meeting, Scoliosis Research Society, New Orleans, 1983.

Dean, R.R., A.L. Beckman, T.L. Stanton, and J.K. Wamsley.  Autoradiography of hibernation-induced changes in brain opioid receptors.  Trans. Am. Soc. Neurochem. 15:182, 1984.

Beckman, A.L. and C. Llados-Eckman.  Hibernation bout duration is reduced by infusion of met-enkephalin into the lateral cerebral ventricle of the ground squirrel.  Fed. Proc. 44:422, 1985.

Stanton, T.L., N. Sartin, and A.L. Beckman.  Changes in body temperature and metabolic rate following preoptic/anterior hypothalamic microinjection of met-enkephalinamide in rats.  Fed. Proc. 44:423, 1985.

Salzman, S.K., C. Llados-Eckman, G.D. MacEwen, A.L. Beckman, and E. Hirofuji.  Effect of acute spinal trauma on monoamine content and utilization.  Fed. Proc. 44:1390, 1985.

Salzman, S.K., P.B. Knight, E. Hirofugi, C. Llados-Eckman, A. Winokur, and A.L. Beckman.  TRH and 5-HT responses to acute spinal trauma.  Soc. Neurosci. Abstr. 12:625, 1986.

Jourdan, M.L., A.L. Beckman, and L.C.H. Wang.  Morphine physical dependence during hypothermia in the ground squirrel (Citellus lateralis).  Soc. Neurosci. Abstr. 15:637, 1989.

Mueller, G.P., T.L. Stanton, and A.L. Beckman.  Hibernation differentially affects beta-endorphin (B-END) and cholecystokinin octapeptide (CCK-8) concentrations in the pituitary and central nervous system of ground squirrels.  FASEB J. 4:A733, 1990.

Beckman, A.L., T. Beaver, F. Lewis, and P. Bachelor.  CNS mechanisms underlying development of morphine dependence remain functional during CNS depression induced by anesthesia in rat and ground squirrel.  The Pharmacologist 33:192, 1991.

Lewis, F.C., T.A. Beaver, and A.L. Beckman.  Morphine physical dependence in the hibernator: dose-response studies during the nonhibernating state in ground squirrels (Citellus lateralis).  FASEB J. 6:A985, 1992.

Beckman, A.L., T.M. MacCreadie, and J. Robert Newman.  Development of tolerance to morphine analgesia during the nonhibernating state in ground squirrels (Citellus lateralis).  FASEB J. 6:A986, 1992.

Mueller, G.P., T.A. Ford, T.L. Stanton, and A.L. Beckman.  Regulation of peptides and peptidylglycine alpha-amidating monooxygenase (PAM) activity in the pituitary and brain of hibernating ground squirrels.  Soc. Neurosci. Abstr. 18:763, 1992.

Beaver, T.A., F.G. Lewis, and A.L. Beckman.  Hibernation-induced reduction of morphine physical dependence in ground squirrels: preliminary dose-response studies.  NIDA Res. Monogr. 132:362, 1993.

MacCreadie, T.M., J.R. Newman, and A.L. Beckman.  Tolerance to morphine analgesia: preliminary studies using the skin-twitch assay in the ground squirrel hibernator model, Citellus lateralis.  NIDA Res. Monogr. 132:363, 1993.

Schrater, P.R., T.L. Stanton, J.R. Newman, L.M. Rodriguez, and A.L. Beckman.  Changes in striatal dopamine metabolism during the development of morphine dependence: preliminary observations using in vivo microdialysis in rats.  NIDA Res. Monogr. 132:393, 1993.

Beckman, A.L., S.K. Ball, J.R. Newman, E.A. Majane, and H-Y.T. Yang.  Regional content of neuropeptide-FF in the brain of the ground squirrel (Citellus lateralis) in the non-hibernating and hibernating states.  FASEB J. 8:A626, 1994.

Kim, M.M., J.R. Newman, and A.L. Beckman.  b-Endorphin action during hibernation: Dose-dependent reduction of bout length produced by intracerebroventricular infusion in ground squirrels (Citellus literalis).  FASEB J. 8:A844, 1994.

Beckman, A.L., J.R. Newman, R. Valencia, and F.M. Leslie.  Hibernation-related regional changes in brain mu, delta, and kappa opioid receptor binding.  NIDA Res. Monogr. 162:160, 1996.