WHY IS C-16 ESTROGEN DANGEROUS?
It is necessary to say a few more things about the "pathophysiological mechanism" that can occur in women who are at risk for breast or reproductive tissue cancer, or that does occur in women who have it. In this context, since the most important binding site for estrogen is the binding site (on the DNA chromosomal material) that controls cell division, any cell into which 16-hydroxyestrone (let's now call it simply C-16) enters can be the one cell that starts cancer in this tissue. (Sloesand et al 1981, Swaneck 1988, Lustig 1989, Messina et al, 1991)