WHAT ABOUT OTHER VALUABLE PLANT DIETARY SUBSTANCES?
Other substances, in addition to I-3-C and ascorbigen, are also known to slow or limit cell division in the prostate gland. One of them is a substance known as "serenoa reopens B". This is found in "pho inta" berries (traditionally consumed by Seminole indians of North America). It not only will slow or inhibit the conversion of testosterone to DHT, but it acts to inhibit the binding of DHT to the DNA chromosomal material within steroid-sensitive cells of the male reproductive system.
Both of the major breakdown or deactivation pathways for estradiol involve oxidations by MFOs. (One of these pathways puts two hydroxyl groups on the 6-carbon A-ring, making it a catechol estrogen which will be rapidly cleared by the kidneys.) (ref needed-find refs 18,19) The important thing to remember is that anything that will lower the estrogen/testosterone ratio in aging men by lowering the rate at which 17 beta estradiol is formed (by the aromatization of testosterone) will be beneficial. Men should be motivated to lower their risk of cancer in any steroid sensitive tissue. This includes not only tissue of the prostate gland, but also tissue in other areas such as fat-laden breast tissue. (Castro-Magana et al 1991, Wilson et al 1980, Moore, 1984)