HOW CAN WE DETOXIFY CARCINOGENS?
The MFO enzyme group, certainly acting as a primary detoxification system, would be expected to be very high in the liver (compared with the intestinal tract and lungs) considering the physiological roles played by the liver. But, nevertheless, the MFO activity in the lungs and intestinal tract can be greatly increased by increasing the I-3-C activation of ascorbigen that takes place in them. We must credit McDanell with the discovery that the MFO activation by ascorbigen causes the destruction of toxins in the diet before those toxins have a chance to enter the intestinal bloodstream and be on their way to the liver. McDanell et al 1987).
McDanell observed that the supplementary I-3-C amount that he used increased the activity of the general MFO enzyme system in the small intestine by a factor of 8, in the large intestine by a factor of 5, and in the liver by a factor of 14. But when he measured the activity of the specific MFO activator, ascorbigen, he found it to be increased by a factor of 45 in the small intestine, and also by a factor of 45 in the large intestine. This evidence allows us to predict that either the consumption of Brassica vegetables or the use of ascorbigen and I-3-C together as a dietary supplement should result in a very large reduction in the incidence of cancers of the intestinal tract (such as colon cancer).
The above explanation is quite lengthy, but the conclusion seems clear. The slower the activation of MFOs, the greater the liklihood that carcinogenic toxins will not only be absorbed and pass via the hepatic portal vein to the liver, but also that they will not be detoxified by the liver, and, by becoming generally distributed throughout the cardiovascular system wreak their carcinogenic havoc almost anywhere in the body. Obviously, if MFO detoxification can occur in the intestinal tract before absorption at all, that is greatly to be preferred. Imagine what a dramatic reduction there could have been in the more than 50,000 lives that colon cancer claims in the United States each year. (Graham et al 1978, Byers and Graham 1984, Amer Cancer Soc 1991).
The evidence now seems clear that the I-3-C and (or from) ascorbigen in Brassica vegetables quickly turns on MFO activity so that it can rapidly detoxify any toxic substance in us upon which MFO's have the ability to act. And this includes the dangerous 16 hydroxyestrone. This is quite likely the best way to greatly reduce the risk of at least the steroid-involved cancers in women (and most likely in men as well).