Dr. Editte Gharakhanian (Biological Sciences)
B.A. Biology,George Mason University, Fairfax, VA. (1983)
Ph.D. Cell, Molecular and Developmental Biology, University of California, Los Angeles. (1988)
Post Doctoral Training: Californa Institute of Technology (1988-1990)
Our laboratory uses Baker's yeast, Saccharomyces cerevisiae, as a model system for cellular, molecular and bioinformatics approaches to study genes involved in lysosomal events. The lysosome of eukaryotic cells is responsible for ion and pH homeostasis, degradation and clearing of unwanted molecules and toxins, receptor down regulation in signal transduction response, and tolerance to a variety of stresses including temperature, nutrient deprivation, and drug toxicity. As such, the lysosome is of interest not only at a basic cell biology level, but also at an applied biomedical level. Defects in lysosomal events are associated with neurodegenerative diseases such as Alzheimers, lysosomal storage diseases such as Tay Sachs, and invasive cancers. Through two different genomic screens, we have identified a number of novel, previously uncharacterized yeast genes involved in lysosomal function, trafficking, and morphology (ENV genes). We are currently studying the phenotypes of mutants deleted in single ENV genes and the ENV genes themselves -- their expression and their protein products. Our goal is to elucidate the specific molecular role of ENV gene products in lysosomal events.
(562 ) 985-4803
(562) 985-8340 (Lab)