Cortagine infused into the medial prefrontal cortex attenuates predator-induced defensive behaviors and Fos protein production in selective nuclei of the amygdala in male CD1 mice

Publication Type:

Journal Article

Source:

Hormones and behavior, Volume 64, Issue 3, p.519-26 (2013)

ISBN:

0018-506X (Linking)

Accession Number:

23845323

URL:

http://www.ncbi.nlm.nih.gov/pubmed/23845323

Abstract:

<p>Corticotropin-releasing factor (CRF) plays an essential role in coordinating the autonomic, endocrine and behavioral responses to stressors. In this study, we investigated the role of CRF within the medial prefrontal cortex (mPFC) in modulating unconditioned defensive behaviors, by examining the effects of microinfusing cortagine a selective type-1 CRF receptor (CRF1) agonist, or acidic-astressin a preferential CRF1 antagonist, into the mPFC in male CD-1 mice exposed to a live predator (rat exposure test--RET). Cortagine microinfusions significantly reduced several indices of defense, including avoidance and freezing, suggesting a specific role for CRF1 within the infralimbic and prelimbic regions of the mPFC in modulating unconditioned behavioral responsivity to a predator. In contrast, microinfusions of acidic-astressin failed to alter defensive behaviors during predator exposure in the RET. Cortagine microinfusions also reduced Fos protein production in the medial, central and basomedial, but not basolateral subnuclei of the amygdala in mice exposed to the rat predatory threat stimulus. These results suggest that CRF1 activation within the mPFC attenuates predator-induced unconditioned anxiety-like defensive behaviors, likely via inhibition of specific amygdalar nuclei. Furthermore, the present findings suggest that the mPFC represents a unique neural region whereby activation of CRF1 produces behavioral effects that contrast with those elicited following systemic administration of CRF1 agonists.</p>

Notes:

Horm BehavPentkowski, Nathan STovote, PhilipZavala, Arturo RLitvin, YoavBlanchard, D CarolineSpiess, JoachimBlanchard, Robert JP20MD003942/MD/NIMHD NIH HHS/Horm Behav. 2013 Aug;64(3):519-26. doi: 10.1016/j.yhbeh.2013.06.008. Epub 2013 Jul 9.

Research was supported in part by the National Institute On Minority Health And Health Disparities of the National Institutes of Health under Award Number P20MD003942. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.